KOZUKA JUNKO

Objective: This study aimed to investigate the relationship between the change of language symptoms and the change of regional cerebral blood flow (rCBF) in the recovery process of two children with acquired aphasia caused by infarctions from Moyamoya disease with an onset age of 8 years. Methods: We compared the results for the Standard Language Test of Aphasia (SLTA) with rCBF changes in 7 language regions.in the left hemisphere and their homologous regions in the right hemisphere at 4 time points from 3 weeks for up to 5 years after the onset of aphasia, while controlling for the effect of age. Results: In both cases, strong correlations were seen within a hemisphere between adjacent regions or regions that are connected by neuronal fibers, and between some language regions in the left hemisphere and their homologous regions in the right hemisphere. Conversely, there were differences between the two cases in the time course of rCBF changes during their recovery process. Conclusion: Consistent with previous studies, the current study suggested that both hemispheres were involved in the long-term recovery of language symptoms in children with acquired aphasia. We suggest that the differences between both cases during their recovery process might be influenced by the brain states before aphasia, by which hemisphere was affected, and by the timing of the surgical revascularization procedure. However, the changes were observed in the data obtained for rCBF with strong correlations with the changes in language performance, so it is possible that rCBF could be used as a biomarker for language symptom changes. (C) 2017 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.